Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder.

Abstract

Hepatotoxic effect related to Ganoderma lucidum (Lingzhi) mushroom powder was first described in a patient from Hong Kong in 2004. In 2005, the authors experienced a case of fatal fulminant hepatitis associated with such a preparation. Both patients had taken other therapeutic agents and traditionally boiled Lingzhi without any toxic effect. After switching to taking Lingzhi in powder form for 1-2 months, the hepatotoxic episode occurred in both patients. The toxic role of Lingzhi powder needs close monitoring in the future, especially in combination with other drugs.

• Authors: Harirak Wanmuang, Juvady Leopairut, Chomsri Kositchaiwat, Winai Wananukul, Sukhum Bunyaratvej
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 90 Issue 1 Pg. 179-81 (Jan 2007) ISSN: 0125-2208 [Print] Thailand
• PMID: 17621752 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Powders

Topics

• Chemical and Drug Induced Liver Injury (etiology, pathology)
• Drugs, Chinese Herbal (poisoning)
• Fatal Outcome
• Female
• Humans
• Liver (pathology)
• Liver Failure, Acute (etiology, pathology)
• Middle Aged
• Powders
• Reishi
• Wound Healing