[Clinical evaluation of cefdinir 10% granules in children].

Abstract

Cefdinir (CFDN, FK482) was evaluated in children with infections. CFDN was given at a daily dose of 6.4-19.8 mg/kg in 2 or 3 divided portions. CFDN was effective in 94% of 32 cases with respiratory tract, middle ear, urinary tract or skin structure infections. Side effects were loose stool and diarrhea (12.5%). In a pharmacokinetic study, 6.0 mg/kg of CFDN was given to each of the subjects before meal. Cmax was 0.81 +/- 0.38 microgram/ml, T 1/2 was 2.31 +/- 0.77 hours. Antibacterial activity against Staphylococcus aureus was the most excellent of oral cephem antibiotics tested. The data suggest that CFDN 10% granular preparation is safe and effective when used in children with infections caused by susceptible bacteria.

• Authors: H Meguro, A Mori, R Fujii, I Terashima
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 44 Issue 10 Pg. 1061-8 (Oct 1991) ISSN: 0368-2781 [Print] Japan
• PMID: 1762162 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• Dosage Forms
• Cefdinir

Topics

• Administration, Oral
• Age Factors
• Bacteria (drug effects)
• Bacterial Infections (drug therapy, microbiology)
• Cefdinir
• Cephalosporins (administration & dosage, pharmacokinetics, pharmacology)
• Child
• Child, Preschool
• Dosage Forms
• Drug Evaluation
• Drug Resistance, Microbial
• Female
• Humans
• Infant
• Male