Abstract | PURPOSE OF REVIEW: To discuss the development and current status of blood substitutes, including hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbons. Research in this field offers an important view into the future of transfusion medicine in the operating room, as well as in trauma and combat arenas. RECENT FINDINGS: SUMMARY: Polymerized hemoglobin preparations have proven most successful in clinical trials due to their improved side-effect profile. The goal is to evaluate blood substitutes with enhanced intravascular retention, reduced osmotic activity, and attenuated hemodynamic derangements such as vasoconstriction. Although not without substantial morbidity and mortality, the current safety of allogeneic blood transfusion demands that comparative studies show minimal adverse effects, as well as efficacy and potential for novel applications.
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Authors | Jonathan S Jahr, Valeri Walker, Katayoon Manoochehri |
Journal | Current opinion in anaesthesiology
(Curr Opin Anaesthesiol)
Vol. 20
Issue 4
Pg. 325-30
(Aug 2007)
ISSN: 0952-7907 [Print] United States |
PMID | 17620840
(Publication Type: Journal Article, Review)
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Chemical References |
- Blood Substitutes
- Fluorocarbons
- Hemoglobins
- Oxygen
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Topics |
- Blood Substitutes
(chemistry, classification, therapeutic use)
- Fluorocarbons
(adverse effects)
- Hemoglobins
(adverse effects, metabolism)
- Humans
- Oxygen
(metabolism)
- Transfusion Reaction
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