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In vivo activity of a novel polymeric guanidine in experimental skin infection with methicillin-resistant Staphylococcus aureus.

Abstract
The in vivo efficacy of the novel polymeric guanidine AKACID Plus was evaluated in a guinea pig model of experimental skin infection with methicillin-resistant Staphylococcus aureus (MRSA). Topical application of AKACID Plus at concentrations of > or =0.5% was as effective as mupirocin 2% cream in the treatment of superficial skin infection with MRSA.
AuthorsChristina Kratzer, Selma Tobudic, Karin Macfelda, Wolfgang Graninger, Apostolos Georgopoulos
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 51 Issue 9 Pg. 3437-9 (Sep 2007) ISSN: 0066-4804 [Print] United States
PMID17620381 (Publication Type: Journal Article)
Chemical References
  • AKACID Plus
  • Anti-Bacterial Agents
  • Guanidines
  • Polymers
  • Mupirocin
Topics
  • Animals
  • Anti-Bacterial Agents (therapeutic use)
  • Colony Count, Microbial
  • Dose-Response Relationship, Drug
  • Female
  • Guanidines (therapeutic use)
  • Guinea Pigs
  • Male
  • Methicillin Resistance
  • Mupirocin (pharmacology)
  • Polymers (therapeutic use)
  • Skin (microbiology)
  • Skin Diseases, Infectious (drug therapy)
  • Staphylococcal Infections (drug therapy, microbiology)

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