In vivo activity of a novel polymeric guanidine in experimental skin infection with methicillin-resistant Staphylococcus aureus.

The in vivo efficacy of the novel polymeric guanidine AKACID Plus was evaluated in a guinea pig model of experimental skin infection with methicillin-resistant Staphylococcus aureus (MRSA). Topical application of AKACID Plus at concentrations of > or =0.5% was as effective as mupirocin 2% cream in the treatment of superficial skin infection with MRSA.
AuthorsChristina Kratzer, Selma Tobudic, Karin Macfelda, Wolfgang Graninger, Apostolos Georgopoulos
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 51 Issue 9 Pg. 3437-9 (Sep 2007) ISSN: 0066-4804 [Print] United States
PMID17620381 (Publication Type: Journal Article)
Chemical References
  • AKACID Plus
  • Anti-Bacterial Agents
  • Guanidines
  • Polymers
  • Mupirocin
  • Animals
  • Anti-Bacterial Agents (therapeutic use)
  • Colony Count, Microbial
  • Dose-Response Relationship, Drug
  • Female
  • Guanidines (therapeutic use)
  • Guinea Pigs
  • Male
  • Methicillin Resistance
  • Mupirocin (pharmacology)
  • Polymers (therapeutic use)
  • Skin (microbiology)
  • Skin Diseases, Infectious (drug therapy)
  • Staphylococcal Infections (drug therapy, microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: