Abstract |
The clinical efficacy, safety and usefulness of Rokitamycin (RKM), a new macrolide antibiotic, were compared with those of Ofloxacin (OFLX) for the treatment of Campylobacter enteritis by a double blind method. The daily dose level of RKM or OFLX was 600 mg. They were orally administered in three divided doses for 5 days. Of 223 cases studied, 106 cases were diagnosed as Campylobacter enteritis. Ninety cases (RKM group: 50, OFLX group: 40) except for 16 excluded or drop-out cases were analysed. There was no significant difference between the two groups in any background factors. The effectiveness and usefulness was evaluated in 88 cases (RKM group: 48, OFLX group: 40). The results obtained were as follows: 1. In a total of 82 strains of Campylobacter jejuni/coli (RKM group: 42, OFLX group: 40), the bacteriological efficacy rate of RKM (95.2%) was superior to that of OFLX (70.0%) with a significant difference (p = 0.006). 2. In 76 symptomatic patients (RKM group: 42, OFLX group: 34) on the day of the beginning of drug administration, the clinical efficacy rate was 97.6% in the RKM group and 85.3% in the OFLX group with no significant difference between the two groups. 3. In 88 evaluable patients, the global clinical efficacy rate of RKM (95.8%) was superior to that of OFLX (67.5%) with a significant difference (p = 0.001). 4. Side effect was observed in 1 (1.9%) of the 54 patients in the RKM group and none of the 44 patients in the OFLX group. Slightly abnormal laboratory findings were seen in 4 (10.8%) of the 37 patients treated with RKM and 3 (9.7%) of the 31 patients treated with OFLX, but there was no significant difference between the two groups. 5. In 88 evaluable patients, the clinical usefulness of RKM (91.7%) was superior to that of OFLX (67.5%) with a significant difference (p = 0.01). From these results, RKM is considered to be a very useful agent for the treatment of Campylobacter enteritis.
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Authors | M Obana, I Tomizawa, Y Takizawa, Y Nitta, H Sagara, T Seo, J Sato, T Tsunoda, S Ota, A Machii |
Journal | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
(Kansenshogaku Zasshi)
Vol. 65
Issue 9
Pg. 1165-82
(Sep 1991)
ISSN: 0387-5911 [Print] Japan |
PMID | 1761896
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Miocamycin
- Ofloxacin
- rokitamycin
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Topics |
- Adolescent
- Adult
- Aged
- Campylobacter Infections
(drug therapy)
- Campylobacter coli
- Campylobacter jejuni
- Double-Blind Method
- Enteritis
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Miocamycin
(analogs & derivatives, therapeutic use)
- Ofloxacin
(therapeutic use)
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