| Abstract | Both slow-release (SR) and regular-release (RR) metformin were effective in the treatment of type 2 diabetes mellitus. We compare the efficacy, safety, and effects on serum adipocytokines and inflammatory markers of both regimens in patients with type 2 diabetes mellitus. A prospective, randomized, double-blind study enrolled 55 patients with type 2 diabetes mellitus, which were randomly assigned to receive either metformin SR or RR (at a maximal dosage of 2000 mg/d for 12 weeks). Glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose, adipocytokines, C-reactive protein, and insulin resistance and pancreatic beta-cell function were measured before and after treatment. Significant decreases (P<.001) in mean HbA1c and fasting plasma glucose levels were observed in each group. However, the mean changes in HbA1c from baseline to end point in the 2 groups were not significantly different. Changes in metabolic parameters were similar except that a decreased total cholesterol level was observed in the metformin RR group. Neither regimen treatment had any influence on insulin resistance, but metformin RR improved beta-cell function. Neither regimen had an effect on serum adipocytokines or inflammatory markers. Once-daily metformin SR was as safe and effective as metformin RR in type 2 diabetic patients. Neither dosage form affected serum adipocytokines and inflammatory markers. |
| Authors | Chang-Hsun Hsieh, Chih-Tseung He, Chien-Hsing Lee, Ling-Yi Wu, Yi-Jen Hung
(Affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan, ROC.)
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| Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 56
Issue 8
Pg. 1087-92
(Aug 2007)
ISSN: 0026-0495 United States |
| PMID | 17618954
(Publication Type: Journal Article, Randomized Controlled Trial)
|
| Chemical References |
- Adiponectin
- Blood Glucose
- Cytokines
- Delayed-Action Preparations
- Hemoglobin A, Glycosylated
- Hypoglycemic Agents
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Cholesterol
- Metformin
- C-Reactive Protein
- Nicotinamide Phosphoribosyltransferase
- nicotinamide phosphoribosyltransferase, human
|
| Topics |
- Adiponectin
(blood)
- Adult
- Aged
- Blood Glucose
(metabolism)
- C-Reactive Protein
(metabolism)
- Chemistry, Pharmaceutical
- Cholesterol
(blood)
- Cytokines
(blood, metabolism)
- Delayed-Action Preparations
- Diabetes Mellitus, Type 2
(blood)
- Double-Blind Method
- Female
- Hemoglobin A, Glycosylated
(metabolism)
- Humans
- Hypoglycemic Agents
(administration & dosage, therapeutic use)
- Inflammation
(metabolism)
- Interleukin-6
(blood)
- Male
- Metformin
(administration & dosage, therapeutic use)
- Middle Aged
- Nicotinamide Phosphoribosyltransferase
- Tumor Necrosis Factor-alpha
(blood)
|
