| Abstract | A patient with IgG-kappa-associated subcorneal pustular dermatosis (Sneddon-Wilkinson disease) refractory to dapsone, etretinate, and plasma exchange was successfully treated with corticosteroids. A study of neutrophils from both blood and pustules was carried out before and during treatment. Levels of tumor necrosis factor-alpha were measured in serum, pustules, content, and supernatant of monocytes. The results suggest that a hyperactivation of neutrophils in the skin is due at least partly to excessive production of tumor necrosis factor-alpha. |
| Authors | J J Grob, J L Mege, C Capo, E Jancovicci, J R Fournerie, P Bongrand, J J Bonerandi
(Affiliation: Service de Dermatologie, Hôpital Sainte Marguerite, Marseille, France.)
|
| Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 25
Issue 5 Pt 2
Pg. 944-7
(Nov 1991)
ISSN: 0190-9622 UNITED STATES |
| PMID | 1761776
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Immunoglobulin G
- Tumor Necrosis Factor-alpha
- Methylprednisolone
|
| Topics |
- Aged
- Aged, 80 and over
- Cell Movement
- Humans
- Immunoglobulin G
(analysis)
- Male
- Methylprednisolone
(therapeutic use)
- Neutrophils
(immunology)
- Plasma Exchange
- Skin Diseases, Vesiculobullous
(drug therapy, immunology)
- Tumor Necrosis Factor-alpha
(analysis, biosynthesis)
|
