Role of tumor necrosis factor-alpha in Sneddon-Wilkinson subcorneal pustular dermatosis. A model of neutrophil priming in vivo.

Abstract

A patient with IgG-kappa-associated subcorneal pustular dermatosis (Sneddon-Wilkinson disease) refractory to dapsone, etretinate, and plasma exchange was successfully treated with corticosteroids. A study of neutrophils from both blood and pustules was carried out before and during treatment. Levels of tumor necrosis factor-alpha were measured in serum, pustules, content, and supernatant of monocytes. The results suggest that a hyperactivation of neutrophils in the skin is due at least partly to excessive production of tumor necrosis factor-alpha.

• Authors: J J Grob, J L Mege, C Capo, E Jancovicci, J R Fournerie, P Bongrand, J J Bonerandi
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 25 Issue 5 Pt 2 Pg. 944-7 (Nov 1991) ISSN: 0190-9622 [Print] United States
• PMID: 1761776 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin G
• Tumor Necrosis Factor-alpha
• Methylprednisolone

Topics

• Aged
• Aged, 80 and over
• Cell Movement
• Humans
• Immunoglobulin G (analysis)
• Male
• Methylprednisolone (therapeutic use)
• Neutrophils (immunology)
• Plasma Exchange
• Skin Diseases, Vesiculobullous (drug therapy, immunology)
• Tumor Necrosis Factor-alpha (analysis, biosynthesis)