Role of tumor necrosis factor-alpha in Sneddon-Wilkinson subcorneal pustular dermatosis. A model of neutrophil priming in vivo.

A patient with IgG-kappa-associated subcorneal pustular dermatosis (Sneddon-Wilkinson disease) refractory to dapsone, etretinate, and plasma exchange was successfully treated with corticosteroids. A study of neutrophils from both blood and pustules was carried out before and during treatment. Levels of tumor necrosis factor-alpha were measured in serum, pustules, content, and supernatant of monocytes. The results suggest that a hyperactivation of neutrophils in the skin is due at least partly to excessive production of tumor necrosis factor-alpha.
AuthorsJ J Grob, J L Mege, C Capo, E Jancovicci, J R Fournerie, P Bongrand, J J Bonerandi
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 25 Issue 5 Pt 2 Pg. 944-7 (Nov 1991) ISSN: 0190-9622 [Print] UNITED STATES
PMID1761776 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin G
  • Tumor Necrosis Factor-alpha
  • Methylprednisolone
  • Aged
  • Aged, 80 and over
  • Cell Movement
  • Humans
  • Immunoglobulin G (analysis)
  • Male
  • Methylprednisolone (therapeutic use)
  • Neutrophils (immunology)
  • Plasma Exchange
  • Skin Diseases, Vesiculobullous (drug therapy, immunology)
  • Tumor Necrosis Factor-alpha (analysis, biosynthesis)

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