Abstract |
Women with mutations in BRCA1 or BRCA2 are at tremendously increased lifetime risk of both breast and BRCA-associated gynecologic (ovarian, fallopian tube, and primary peritoneal) cancer. Because of limitations in the efficacy of available screening and chemopreventive approaches for women with a mutation in one of these genes, surgical risk reduction, particularly risk-reducing salpingo-oophorectomy (RRSO), has become an important component of the management options in hereditary breast- ovarian cancer syndrome. This article will review the rationale and efficacy of RRSO for prevention of breast and BRCA-associated gynecologic cancer. Surgical technique and methods of pathologic evaluation will be presented. Controversies regarding uterine preservation and post-RRSO hormone replacement therapy will be addressed. Considerations that may impact the appropriate timing of the procedure will be reviewed, and the potential role of RRSO in BRCA-negative hereditary breast cancer families will also be discussed.
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Authors | Noah D Kauff, Richard R Barakat |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 25
Issue 20
Pg. 2921-7
(Jul 10 2007)
ISSN: 1527-7755 [Electronic] United States |
PMID | 17617523
(Publication Type: Journal Article, Review)
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Chemical References |
- BRCA1 Protein
- BRCA2 Protein
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Topics |
- BRCA1 Protein
(genetics)
- BRCA2 Protein
(genetics)
- Breast Neoplasms
(genetics)
- DNA Mutational Analysis
- Female
- Genes, BRCA1
- Genes, BRCA2
- Germ-Line Mutation
- Humans
- Models, Anatomic
- Ovarian Neoplasms
(genetics)
- Ovariectomy
(instrumentation, methods)
- Risk
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