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Effect of 1- and 10-day administration of tepoxalin on minimum alveolar concentration of isoflurane and sevoflurane in dogs.

Abstract
Analgesics given preoperatively have the potential to decrease the amount of inhalant anesthetics required intraoperatively (i.e., to decrease the minimum alveolar concentration, or MAC, for the inhalant). Tepoxalin is an NSAID approved for the treatment of arthritis in dogs in the United States and, hence, could be administered to patients undergoing anesthesia. In this study, administration of a single dose or a 10-day course of tepoxalin did not affect the MAC for isoflurane or sevoflurane.
AuthorsM A Crist, N S Matthews, N L Oberle, C Pappas
JournalVeterinary therapeutics : research in applied veterinary medicine (Vet Ther) Vol. 8 Issue 2 Pg. 107-12 ( 2007) ISSN: 1528-3593 [Print] United States
PMID17616945 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anesthetics, Inhalation
  • Anti-Inflammatory Agents, Non-Steroidal
  • Methyl Ethers
  • Pyrazoles
  • Sevoflurane
  • Isoflurane
  • tepoxalin
Topics
  • Administration, Inhalation
  • Anesthetics, Inhalation (administration & dosage)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
  • Dogs (physiology)
  • Drug Interactions
  • Female
  • Isoflurane (administration & dosage)
  • Male
  • Methyl Ethers (administration & dosage)
  • Preanesthetic Medication (veterinary)
  • Pulmonary Alveoli (drug effects, metabolism)
  • Pyrazoles (pharmacology, therapeutic use)
  • Random Allocation
  • Sevoflurane
  • Treatment Outcome

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