Comparative efficacy and safety of cefprozil and cefaclor in the treatment of acute uncomplicated urinary tract infections.

Abstract

Cefprozil is a new oral semi-synthetic cephalosporin with broad antibacterial spectrum and prolonged serum elimination half-life. In vitro, cefprozil demonstrates excellent activity against common urinary tract pathogens such as Escherichia coli and Klebsiella pneumoniae. Cefprozil, 500 mg once a day, was compared to cefaclor, 250 mg three times a day, in an open, randomized, comparative, clinical trial for the treatment of acute, uncomplicated, urinary tract infection. One hundred and two adult patients were eligible for safety evaluation; four patients were excluded due to side-effects (abdominal discomfort, nausea and vomiting). Ninety-eight patients were eligible for evaluation of efficacy. Clinical and bacteriological responses were comparable for both antibiotics. Leucopenia, nausea, and vaginal yeast infections were slightly more common in the cefprozil group. Cefprozil, 500 mg once daily, appears to be an appropriate alternative for the treatment of acute, uncomplicated urinary tract infections.

• Authors: J C Christenson, W M Gooch, J N Herrod, E Swenson
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 28 Issue 4 Pg. 581-6 (Oct 1991) ISSN: 0305-7453 [Print] England
• PMID: 1761453 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cephalosporins
• cefprozil
• Cefaclor

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Bacteria (drug effects)
• Cefaclor (adverse effects, pharmacokinetics, therapeutic use)
• Cephalosporins (adverse effects, pharmacokinetics, therapeutic use)
• Half-Life
• Humans
• Microbial Sensitivity Tests
• Middle Aged
• Urinary Tract Infections (drug therapy, microbiology)