Participation of opioid peptide (beta-endorphin) and norepinephrine in the control of compound 48/80-induced hypovolemic thirst in the rats.

Abstract

1. Subcutaneous (s.c.) administration of compound 48/80 elicited the increases of water intake, plasma beta-endorphin-like immunoreactivity, hypothalamic 3-methoxy-4-hydroxyphenylethyleneglycol sulfate and Hct in the rats. 2. The s.c. pretreatment of naloxone reduced the compound 48/80-induced water intake but had no effects on other variables. 3. Intracerebroventricular (i.c.v.) injection of naloxone attenuated the compound 48/80- and i.c.v. injected angiotensin II (ANG II)-induced water intake. 4. The hypothalamic norepinephrine metabolism was increased by s.c. injection of compound 48/80 but not by i.c.v. ANG II. 5. The present data suggest the possible involvement of opioid peptide (beta-endorphin) on the compound 48/80- and ANG II-induced thirst. However, it is uncertain whether hypothalamic norepinephrine is involved in the hypovolemic thirst mediated via stimulation of renin-angiotensin system.

• Authors: H Izumi
• Journal: General pharmacology (Gen Pharmacol) Vol. 22 Issue 5 Pg. 825-9 ( 1991) ISSN: 0306-3623 [Print] England
• PMID: 1761187 (Publication Type: Journal Article)

Chemical References

• Catecholamines
• Angiotensin II
• Naloxone
• p-Methoxy-N-methylphenethylamine
• Methoxyhydroxyphenylglycol
• beta-Endorphin
• Norepinephrine

Topics

• Angiotensin II (administration & dosage, pharmacology)
• Animals
• Blood Volume (physiology)
• Catecholamines (metabolism)
• Hypothalamus (drug effects, metabolism)
• Injections, Intraventricular
• Injections, Subcutaneous
• Male
• Methoxyhydroxyphenylglycol (metabolism)
• Naloxone (administration & dosage, pharmacology)
• Norepinephrine (physiology)
• Rats
• Rats, Inbred Strains
• Thirst (drug effects)
• beta-Endorphin (physiology)
• p-Methoxy-N-methylphenethylamine (administration & dosage, pharmacology)