[Meta-analysis on the association of Myocilin Q368X mutation and primary open angle glaucoma].

Abstract

OBJECTIVE:

To study the association between Myocilin (MYOC) Gln368STOP mutation and primary open angle glaucoma (POAG) by means of Meta-analysis.

METHODS:

Odds ratios (OR) of MYOC Gln368STOP genotype distributions in POAG patients verse the controls were analyzed. All the relevant reported studies were identified. Poor-qualified studies were eliminated, and the risk of publication bias was excluded. Meta-analysis software, RevMan 4.2, was applied for investigating heterogeneity among individual studies and summarizing the effects across studies.

RESULTS:

A total of 3077 POAG cases and 2063 controls from 11 studies were included. No heterogeneity among these studies was noticed (P = 0.79). The pooled OR (with 95% CI) of MYOC Gln368STOP in POAG cases versus that in the controls was 6.01 (2.57 - 14.04, P < 0.01).

CONCLUSION:

MYOC Gln368STOP mutation might be associated with the increased risk of POAG and is one of its risk factors.

• Authors: Ting Liu, Xiang-Ge He
• Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology (Zhonghua Yan Ke Za Zhi) Vol. 43 Issue 4 Pg. 361-6 (Apr 2007) ISSN: 0412-4081 [Print] China
• PMID: 17605937 (Publication Type: English Abstract, Journal Article, Meta-Analysis)

Chemical References

• Cytoskeletal Proteins
• Eye Proteins
• Glycoproteins
• trabecular meshwork-induced glucocorticoid response protein

Topics

• Cytoskeletal Proteins (genetics)
• Eye Proteins (genetics)
• Genotype
• Glaucoma, Open-Angle (genetics)
• Glycoproteins (genetics)
• Humans
• Mutation