The X factor: skewing X inactivation towards cancer.

Abstract

Increased expression of the epidermal growth factor receptor HER-2/ErbB2 is frequently observed in breast cancer and is targeted by the anticancer drug Herceptin. Now, Zuo et al. (2007) reveal that an X-linked gene encoding the transcription factor FOXP3 is a breast cancer tumor suppressor that represses expression of HER2/ErbB2.

• Authors: René H Medema, Boudewijn M Th Burgering
• Journal: Cell (Cell) Vol. 129 Issue 7 Pg. 1253-4 (Jun 29 2007) ISSN: 0092-8674 [Print] United States
• PMID: 17604714 (Publication Type: Comment, Journal Article, Review)

Chemical References

• FOXP3 protein, human
• Forkhead Transcription Factors
• Tumor Suppressor Proteins
• Receptor, ErbB-2

Topics

• Animals
• Breast Neoplasms (genetics)
• Cell Transformation, Neoplastic (genetics)
• Chromosomes, Human, X (genetics)
• Forkhead Transcription Factors (genetics)
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• Mutation (genetics)
• Receptor, ErbB-2 (genetics)
• Tumor Suppressor Proteins (genetics)
• X Chromosome Inactivation (genetics)