HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats.

Abstract
During ischemic heart diseases and when heart failure progresses depletion of myocardial energy stores occurs. D-Ribose (R) has been shown to improve cardiac function and energy status after ischemia. Folic acid (FA) is an essential cofactor in the formation of adenine nucleotides. Therefore, we assessed whether chronic R-FA administration during the development of hypertrophy resulted in an improved cardiac function and energy status. In Wistar rats (n = 40) compensatory right ventricular (RV) hypertrophy was induced by monocrotaline (30 mg/kg; MCT), whereas saline served as control. Both groups received a daily oral dose of either 150 mg.kg(-1).day(-1) dextrose (placebo) or R-FA (150 and 40 mg.kg(-1).day(-1), respectively). In Langendorff-perfused hearts, RV and left ventricular (LV) pressure development and collagen content as well as total RV adenine nucleotides (TAN), creatine content, and RV and LV collagen content were determined. In the control group R-FA had no effect. In the MCT-placebo group, TAN and creatine content were reduced, RV and LV diastolic pressure-volume relations were steeper, RV systolic pressures were elevated, RV and LV collagen content was increased, and RV-LV diastolic interaction was altered compared with controls. In the MCT-R-FA group, TAN, RV and LV diastolic stiffness, RV and LV collagen content, and RV-LV diastolic interaction were normalized to the values in the control group while creatine content remained depressed and RV systolic function remained elevated. In conclusion, the depression of energy status in compensated hypertrophic myocardium observed was partly prevented by chronic R-FA administration and accompanied by a preservation of diastolic function and collagen deposition.
AuthorsRegis R Lamberts, Eric Caldenhoven, Mirian Lansink, Gerrit Witte, Rob J Vaessen, John A St Cyr, Ger J M Stienen
JournalAmerican journal of physiology. Heart and circulatory physiology (Am J Physiol Heart Circ Physiol) Vol. 293 Issue 3 Pg. H1869-76 (Sep 2007) ISSN: 0363-6135 [Print] United States
PMID17604325 (Publication Type: Journal Article)
Chemical References
  • Adenine Nucleotides
  • Homocysteine
  • Monocrotaline
  • Collagen
  • Folic Acid
  • Creatine
Topics
  • Adenine Nucleotides (metabolism)
  • Animals
  • Blood Pressure (physiology)
  • Collagen (metabolism)
  • Creatine (metabolism)
  • Dietary Supplements
  • Folic Acid (pharmacology, therapeutic use)
  • Heart Ventricles (drug effects, metabolism)
  • Homocysteine (blood)
  • Hypertrophy, Right Ventricular (chemically induced, drug therapy, physiopathology)
  • Male
  • Monocrotaline
  • Myocardial Contraction (drug effects)
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Ventricular Function, Left (drug effects, physiology)
  • Ventricular Function, Right (drug effects, physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: