Serum levels of insulin-like growth factor-I in relation to organochlorine pesticides exposure.

Abstract

CONTEXT:

Insulin-like growth factor 1 (IGF-I) and organochlorine pesticides (OCs) have been involved in the pathogenesis of several diseases like cancer, diabetes and growth disorders.

OBJECTIVE AND DESIGN:

The potential relationship between the serum levels of various OCs and serum IGF-I was investigated in adults (176 men and 247 women) from a representative sample of the general population of the Canary Islands (Spain).

RESULTS:

After adjustment for potential confounders, which include body mass index, age, and IGF-binding protein-3 (IGFBP-3), IGF-I levels were significantly lower in the 247 women who showed detectable levels of p,p'-DDD (a DDT-metabolite) than in women who presented non-detectable levels of this pesticide (p=0.030), specially in 36-50 years old women. A similar negative relationship was also found between IGF-I and aldrin (a non-DDT-derivative) in women (p=0.049). In the group of 176 men, aldrin seemed to exert a similar negative effect on IGF-I (p=0.046) and this effect was clearly significant in the oldest group (51-65 years) (p=0.009). A non-linear dose-response curve was observed between Total Cyclodienes Body Burden (Total Cyclodienes; sum of aldrin, dieldrin and endrin) and IGF-I in men (p=0.024). These findings suggest that OCs could modulate the IGF-system in a way that is highly influenced by gender, age and by chemical or combination of chemicals implicated. Such circumstances may contribute to the development of a number of diseases related to IGF-I and should be taken into account in public health decisions.

• Authors: Luis D Boada, Pedro C Lara, Eva E Alvarez-León, Antonio Losada, Manuel L Zumbado, Jose M Limiñana-Cañal, Rosa Apolinario, Lluis Serra-Majem, Octavio P Luzardo
• Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (Growth Horm IGF Res) Vol. 17 Issue 6 Pg. 506-11 (Dec 2007) ISSN: 1096-6374 [Print] Scotland
• PMID: 17601760 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Environmental Pollutants
• Hydrocarbons, Chlorinated
• Pesticides
• Insulin-Like Growth Factor I
• Dieldrin
• Endrin
• Aldrin

Topics

• Adult
• Age Distribution
• Aged
• Aldrin (blood)
• Dieldrin (blood)
• Endrin (blood)
• Environmental Pollutants (blood)
• Female
• Health Surveys
• Humans
• Hydrocarbons, Chlorinated (blood)
• Insulin-Like Growth Factor I (metabolism)
• Male
• Middle Aged
• Pesticides (blood)
• Sex Distribution
• Spain