The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex.

Abstract	It has been reported that the RASSF1A tumor suppressor protein controls mitotic progression by binding to and inhibiting Cdc20, an activator of the anaphase-promoting complex. Here, we have used different methods to investigate the association of RASSF1A and Cdc20. We show that there is no interaction between RASSF1A and Cdc20 and conclude that further investigation of the mitotic role of RASSF1A is required.
Authors	Limin Liu, Katrin Baier, Reinhard Dammann, Gerd P Pfeifer
Journal	Cell cycle (Georgetown, Tex.) (Cell Cycle) Vol. 6 Issue 13 Pg. 1663-5 (Jul 01 2007) ISSN: 1551-4005 [Electronic] United States
PMID	17598981 (Publication Type: Letter, Research Support, N.I.H., Extramural)
Chemical References	Cdc20 Proteins Cell Cycle Proteins RASSF1 protein, human Tumor Suppressor Proteins CDC20 protein, human Ubiquitin-Protein Ligase Complexes Anaphase-Promoting Complex-Cyclosome
Topics	Anaphase-Promoting Complex-Cyclosome Cdc20 Proteins Cell Cycle Proteins (metabolism) HeLa Cells Humans Immunoprecipitation Mitosis (physiology) Protein Binding Tumor Suppressor Proteins (metabolism, physiology) Two-Hybrid System Techniques Ubiquitin-Protein Ligase Complexes (metabolism)

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