[Effect of fluvastatin extended release on the protein-lipid structure of erythrocyte membrane and C-reactive protein in patients with hyperlipidemia].

Abstract

UNLABELLED:

The aim of the study was to estimate the effects of 4-weeks therapy of fluvastatin extended release (XL) on lipids serum, C-reactive protein (CRP), erythrocyte structure membrane (thiobarbituric acid reactive substances--TBARS concentrations, membrane cholesterol and the activity of Na+K(+)-ATPase in erythrocytes) in patients with hyperlipidemia without any clinical signs of atherosclerosis.

MATERIAL AND METHODS:

The study comprised 37 persons, including 15 healthy volunteers and 22 patients with hyperlipidemia (TC > 200 mg/dl, LDL-C > 130 mg/dl, TG < 400 mg/dl) treated with fluvastatin XL 80 mg/d. Before and after 4 weeks of active treatment the following parameters were determined: lipids (by enzymatic method using BioMerieux tests), CRP (by immunoturbidimetric method), TBARS concentrations (by method of Stock and Dormandy), membrane cholesterol (method of Ilcy), Na+K(+)-ATPase activity (method of Bartosz et al.).

RESULTS:

It was noticed significantly higher concentrations of CRP, TBARS, membrane cholesterol and lower activity of Na+K(+)-ATPase in erythrocytes of patients with hyperlipidemia than in the control group. Fluvastatin XL caused a significant decrease in serum TC (by 18%), LDL-C (by 24%), TG (by 16%), CRP (by 23%) and TBARS (by 31%), membrane cholesterol (by 30%) in comparison to the initial values before active therapy. The activity of Na+K(+)-ATPase didn't significantly change. The mean values of CRP, TBARS, membrane cholesterol level after active treatment are still higher than in the control group.

CONCLUSION:

The short-term treatment of fluvastatin extended release wasn't enough efficient to compensate disorders in erythrocyte membrane structure of patients with hyperlipidemia.

• Authors: Marlena Broncel, Madgalena Balcerak, Dorota Cieślak, Piotr Duchnowicz, Maria Koter-Michalak, Joanna Sikora, Julita Chojnowska-Jezierska
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 22 Issue 128 Pg. 107-11 (Feb 2007) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Wpływ fluwastatyny o powolnym uwalnianiu na strukture białkowo-lipidowa błon erytrocytów i białko C-reaktywne u pacjentów z hiperlipidemia.
• PMID: 17598653 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Anticholesteremic Agents
• Delayed-Action Preparations
• Fatty Acids, Monounsaturated
• Indoles
• Fluvastatin
• C-Reactive Protein

Topics

• Adult
• Anticholesteremic Agents (administration & dosage)
• C-Reactive Protein (drug effects, metabolism)
• Delayed-Action Preparations (administration & dosage)
• Erythrocyte Membrane (drug effects, metabolism)
• Fatty Acids, Monounsaturated (administration & dosage)
• Female
• Fluvastatin
• Humans
• Hyperlipidemias (drug therapy, metabolism)
• Indoles (administration & dosage)
• Lipid Metabolism (drug effects)
• Male
• Middle Aged
• Reference Values
• Treatment Outcome