Treatment of ocular surface syndrome after LASIK with autologous platelet-rich plasma.

Abstract

PURPOSE:

To ascertain the usefulness of platelet-rich plasma in the treatment of patients suffering from symptomatic ocular surface syndrome following LASIK.

METHODS:

Twenty-six eyes (9 women and 4 men) affected by symptomatic ocular surface syndrome were treated with topical eye drops of autologous platelet-rich plasma and results were reported at 4 weeks. Topical platelet-rich plasma was prepared from total blood and enriched in platelets by centrifugation.

RESULTS:

Eighty-five percent of patients experienced significant improvement of symptoms; best spectacle-corrected visual acuity increased 1 to 2 lines in 54%; fluorescein staining analysis showed a 69% full fluorescein disappearance; and tear break-up time increased > 2 seconds in 46%. Only one patient developed intolerance to platelet-rich plasma after 4 weeks.

CONCLUSIONS:

Autologous platelet-rich plasma was effective in the treatment of patients with ocular surface syndrome following LASIK, with symptoms generally relieved and a positive effect on punctate keratitis.

• Authors: Jorge L Alio, Silvia Pastor, Jose Ruiz-Colecha, Alejandra Rodriguez, Alberto Artola
• Journal: Journal of refractive surgery (Thorofare, N.J. : 1995) (J Refract Surg) Vol. 23 Issue 6 Pg. 617-9 (Jun 2007) ISSN: 1081-597X [Print] United States
• PMID: 17598582 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ophthalmic Solutions

Topics

• Administration, Topical
• Adult
• Corneal Diseases (etiology, therapy)
• Female
• Follow-Up Studies
• Humans
• Keratomileusis, Laser In Situ (adverse effects)
• Male
• Middle Aged
• Myopia (surgery)
• Ophthalmic Solutions (administration & dosage)
• Pilot Projects
• Platelet-Rich Plasma
• Visual Acuity
• Wound Healing