Inhibitory effect of dauricine on inflammatory process following focal cerebral ischemia/reperfusion in rats.

Abstract	Our previous experimental studies showed that dauricine could protect the brain from ischemic damage, but the underlying mechanisms were unknown. In this study, we investigated the effect of dauricine on the changes of the inflammation process induced by ischemia/reperfusion (I/R). After I/R, the enzyme activity of MPO, the expression of ICAM-1 and the transcription of IL-1beta and TNF-alpha mRNA were all significantly increased (p < 0.01). And after treatment with dauricine, they were all significantly reduced compared to the vehicle-treated I/R group (p < 0.05 or p < 0.01). These results suggest that dauricin attenuates the inflammation process induced by I/R. The neuroprotective effect of dauricine may partly due to the inhibition acute inflammation induced by I/R.
Authors	Xiao-Yan Yang, Shi-Qin Jiang, Li Zhang, Qiang-Ni Liu, Pei-Li Gong
Journal	The American journal of Chinese medicine (Am J Chin Med) Vol. 35 Issue 3 Pg. 477-86 ( 2007) ISSN: 0192-415X [Print] Singapore
PMID	17597506 (Publication Type: Journal Article)
Chemical References	Alkaloids Anti-Inflammatory Agents, Non-Steroidal Benzylisoquinolines Interleukin-1beta RNA, Messenger Tetrahydroisoquinolines Tumor Necrosis Factor-alpha Intercellular Adhesion Molecule-1 dauricine Peroxidase
Topics	Alkaloids (pharmacology) Animals Anti-Inflammatory Agents, Non-Steroidal (pharmacology) Benzylisoquinolines (pharmacology) Brain (blood supply, metabolism) Cell Movement (drug effects) Inflammation (metabolism, prevention & control) Intercellular Adhesion Molecule-1 (metabolism) Interleukin-1beta (genetics, metabolism) Male Neutrophils (drug effects, metabolism) Peroxidase (metabolism) RNA, Messenger (metabolism) Rats Rats, Sprague-Dawley Reperfusion Injury (drug therapy, metabolism) Tetrahydroisoquinolines (pharmacology) Transcription, Genetic Tumor Necrosis Factor-alpha (genetics, metabolism)

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