Abstract | BACKGROUND: Mistletoe preparations such as Iscador are commonly used in complementary medication for many cancer indications, particularly solid cancers. The efficacy of this complementary therapy is still controversial. OBJECTIVE: PATIENTS AND METHODS: Prospective recruitment and long-term follow-up was carried out in 3 controlled cohort studies: In a randomized matched-pair study (19 pairs), cervical cancer patients with distant metastases and no mistletoe therapy were matched for prognostic factors. By paired random allocation, one of the patients was recommended mistletoe therapy by the attending physician. In 2 non-randomized matched-pair studies, cervical cancer patients without (102) and with (66) metastases, who already received mistletoe therapy, were matched with control patients without Iscador therapy. RESULTS: For survival, the non-randomized studies showed significant effects in favor of Iscador therapy: hazard ratio (HR) estimate and 95% confidence interval (CI): 0.23 (0.14-0.39) and 0.37 (0.17-0.80), respectively. An effect of long-term Iscador therapy on tumor progression was not seen. Psychosomatic self-regulation in the Iscador group improved significantly within 12 months compared with the control group in the randomized as well as in 1 non-randomized study ( cervical cancer without metastases): estimate of the median difference and 95% CI: 0.70 (0.15-1.05) and 0.25 (0.15-0.35), respectively. CONCLUSION:
Iscador may have the effect of prolonging overall survival of cervical cancer patients. In the short term, psychosomatic self-regulation increases more markedly under complementary Iscador therapy than under conventional therapy alone.
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Authors | Ronald Grossarth-Maticek, Renatus Ziegler |
Journal | Forschende Komplementarmedizin (2006)
(Forsch Komplementmed)
Vol. 14
Issue 3
Pg. 140-7
(Jun 2007)
ISSN: 1661-4119 [Print] Switzerland |
PMID | 17596694
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Plant Extracts
- Plant Proteins
- viscum album peptide
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Topics |
- Antineoplastic Agents
(therapeutic use)
- Antineoplastic Agents, Phytogenic
(therapeutic use)
- Cohort Studies
- Disease Progression
- Female
- Germany
(epidemiology)
- Humans
- Neoplasm Metastasis
(drug therapy)
- Phytotherapy
- Plant Extracts
(therapeutic use)
- Plant Proteins
(therapeutic use)
- Prospective Studies
- Survival Analysis
- Treatment Outcome
- Uterine Cervical Neoplasms
(drug therapy, mortality, pathology)
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