The purpose of the given work was studying influence of a preparation
Plaferon on the process of healing burned
wounds. Experiments was carried out on 30 rats Wistar (the mass of body 220-250 g), that was divided into 3 groups: 1st group (control) -
burns without treatment, 2nd group - treatment only with
Dermazin, 3rd group - treatment with
Dermazin and
Plaferon. As a result of the
burn wound modeling, it is established that under the effect of the thermal interaction the rats of all experimental groups had severe
burns of the skin of III degree. After 5-10 days of observation the degree of necrotic changes in the
burn surface in animal experimental groups was different. They were least expressed in the rats, that obtained treatment by
Plaferon and
Dermazin; further in increasing order of magnitude was located the group of the rats, that obtained treatment only by
Dermazin. The greatest necrotic changes were noted in control animals. With a morphological study of
wound defects with the treatment of
Plaferon and
Dermazin for 30 days in most of rats was noted the epithelization of the
wounds. The rats, that obtained the treatment of the
burns only by preparation of
Dermazin, on the surface of
wounds had the remainders of scab in the form the fibrous- leukocyte layer, under which was located granulating cloth with the regulated motion of weakly-fuxinophilous collagenic fibers. Summing up studying of influence
Plaferon on healing of severe thermal
burn of the skin in rats, it should be noted, that application of
Plaferon together with drawing of preparation
Dermazin on burned surface right after burning
traumas daily, unitary, within the next 30 days noticeably weakens development of severe necrotic processes and accelerates healing of the
burn.