[Interferon in sheep].

Abstract

There is only limited information on sheep interferon available. Recent publications have reported on: 1. an interferon (IFN) alpha subtype, which is secreted by the fetal trophectoderm into the lumen of the uterus between the 10th and 21st day of gestation. It was therefore named ovine trophoblast protein (oTP-1), and is responsible for signalling pregnancy to the ewe via high affinity receptors in the endometrium. It is thought that oTP-1 acts by directly influencing prostaglandin metabolism. 2. the role of lentivirus-induced interferon (LV-IFN) in the pathogenesis of Maedi/Visna. The results indicate that LV-IFN limits viral replication and therefore contributes to virus persistence and is also responsible for a chronic inflammatory process. 3. the mitogen- or antigen-dependent induction of ovine interferon gamma (IFN gamma) and its characterization.

• Authors: M Büttner, K Wertz, W Hollwich
• Journal: Tierarztliche Praxis (Tierarztl Prax) Vol. 19 Issue 5 Pg. 481-5 (Oct 1991) ISSN: 0303-6286 [Print] Germany
• Vernacular Title: Interferon beim Schaf.
• PMID: 1759261 (Publication Type: Journal Article, Review)

Chemical References

• Interferon Type I
• Interferon-alpha
• Pregnancy Proteins
• interferon tau
• Interferon-gamma

Topics

• Animals
• Female
• Interferon Type I
• Interferon-alpha (biosynthesis, physiology)
• Interferon-gamma (biosynthesis, physiology)
• Leukocytes (immunology)
• Pneumonia, Progressive Interstitial, of Sheep (etiology)
• Pregnancy
• Pregnancy Proteins (biosynthesis, physiology)
• Pregnancy, Animal (immunology)
• Sheep (immunology)
• Virus Diseases (etiology, veterinary)