Abstract | BACKGROUND/AIMS: To examine whether genetic differences in hepatitis A virus (HAV) are responsible for the range of clinical severities, we analyzed the HAV 2C genome, whose mutations have previously been shown to be important for enhanced replication in cell culture systems and to be related to virulence in simians. METHODOLOGY: RESULTS: Compared with the sequence of wild-type HAV strain HM-175, the nucleotide sequences of 2C had homology of 89.0 +/- 0.6% in FH, 88.6 +/- 0.9% in AHs, and 89.0 +/- 1.6% in AH. Differences were not statistically significant among the three groups. Deduced amino acid sequences had homology of 97.6 +/- 0.4% in FH, 96.5 +/- 1.9% in AHs, and 96.8 +/- 1.7% in AH. The difference between FH and AH was statistically significant (p < 0.05), although there were no specific nucleotide or amino acid substitutions. CONCLUSIONS:
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Authors | Keiichi Fujiwara, Osamu Yokosuka, Fumio Imazeki, Makoto Miki, Kazuyuki Suzuki, Kiwamu Okita, Eiji Tanaka, Masao Omat |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2007 Apr-May
Vol. 54
Issue 75
Pg. 871-7
ISSN: 0172-6390 [Print] Greece |
PMID | 17591082
(Publication Type: Journal Article)
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Chemical References |
- RNA, Viral
- Viral Proteins
- protein 2C, Hepatitis A virus
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Topics |
- Aged
- Amino Acid Motifs
- Amino Acid Sequence
- Amino Acid Substitution
(genetics)
- Asian People
- Binding Sites
- Female
- Genome, Viral
(genetics)
- Hepatitis A
(pathology, virology)
- Hepatitis A Virus, Human
(genetics, pathogenicity)
- Humans
- Liver Failure, Acute
(pathology, virology)
- Male
- Middle Aged
- Molecular Sequence Data
- RNA, Viral
(blood, genetics)
- Sequence Analysis, RNA
- Viral Proteins
(blood, genetics)
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