Abstract | BACKGROUND & AIMS:
Ornithine alpha-ketoglutarate (OKG) is recognized to improve nutritional status in various catabolic states, such as burn injury, trauma, and sepsis. However, in wasting diseases, such as induced by cancer, the data are scarce and the precise mechanisms by which OKG acts on protein metabolism are still unclear. The aim of this study was to evaluate the ability of OKG to affect protein metabolism in an aggressive model of cancer and to modulate the ubiquitin- proteasome-dependent pathway, which in skeletal muscle is the critical degradative pathway implicated in many catabolic states, including cancer-associated cachexia. METHODS: Experiments were carried out in Yoshida sarcoma-bearing and healthy pair-fed rats. Three groups of 16 young male rats were studied during 9 days following tumor implantation: two groups of tumor-bearing rats fed a balanced regimen enriched with either OKG (5 g/kg body weight/day, OKG-K) or an isonitrogenous mixture of non- essential amino acids (C-K), and one group of healthy pair-fed rats (PF). RESULTS: CONCLUSIONS: These data suggest that OKG action is not universal; i.e. depending upon the model under study. In the circumstances, OKG did not counteract the increase in ubiquitin- proteasome-dependent proteolysis observed in Yoshida sarcoma-bearing rats.
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Authors | Frédéric Segaud, Lydie Combaret, Nathalie Neveux, Didier Attaix, Luc Cynober, Christophe Moinard |
Journal | Clinical nutrition (Edinburgh, Scotland)
(Clin Nutr)
Vol. 26
Issue 5
Pg. 624-30
(Oct 2007)
ISSN: 0261-5614 [Print] England |
PMID | 17590483
(Publication Type: Journal Article)
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Chemical References |
- Methylhistidines
- Proteins
- ornithine alpha-ketoglutarate
- Ornithine
- 3-methylhistidine
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Topics |
- Animals
- Male
- Methylhistidines
(urine)
- Muscle, Skeletal
(metabolism, pathology)
- Muscular Atrophy
(prevention & control)
- Ornithine
(analogs & derivatives, pharmacology)
- Protein Biosynthesis
(drug effects)
- Proteins
(drug effects, metabolism)
- Random Allocation
- Rats
- Rats, Wistar
- Sarcoma, Experimental
(metabolism)
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