Abstract | OBJECTIVE: METHODS: Fourteen children, ages 8-16, with ADHD and TS were treated open-label with ATX for one month. ADHD rating scale scores and SICI, measured with paired-pulse transcranial magnetic stimulation (pTMS), were assessed blindly and independently at treatment onset and one month later. RESULTS: Eleven children, mean ADHD rating scale scores 31.8 (SD 8.2) at onset, completed the study. After one month, ADHDRS changes ranged from an increase of 4 points to a decrease (improvement) of 24 points (mean change -9.6, SD 9.1). The changes in ADHDRS scores correlated with reduction in SICI (r=.74, p=.010). CONCLUSIONS: In children with TS, one month of atomoxetine treatment appears to induce correlated improvements in ADHD and, paradoxically, further reductions in cortical inhibition. SIGNIFICANCE: PTMS-evoked SICI in ADHD with TS may be a biomarker of both deficiency and compensatory changes within cortical interneuronal systems. Effective atomoxetine treatment may augment compensatory processes and thereby reduce SICI.
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Authors | Donald L Gilbert, Jie Zhang, Tara D Lipps, Nina Natarajan, Jared Brandyberry, Zhewu Wang, F Randy Sallee, Eric M Wassermann |
Journal | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
(Clin Neurophysiol)
Vol. 118
Issue 8
Pg. 1835-41
(Aug 2007)
ISSN: 1388-2457 [Print] Netherlands |
PMID | 17588810
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic Uptake Inhibitors
- Propylamines
- Atomoxetine Hydrochloride
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Topics |
- Adolescent
- Adrenergic Uptake Inhibitors
(adverse effects, therapeutic use)
- Atomoxetine Hydrochloride
- Attention Deficit Disorder with Hyperactivity
(drug therapy, etiology, physiopathology, psychology)
- Child
- Cohort Studies
- Female
- Humans
- Male
- Motor Cortex
(drug effects, physiopathology)
- Neural Inhibition
- Propylamines
(adverse effects, therapeutic use)
- Severity of Illness Index
- Single-Blind Method
- Time Factors
- Tourette Syndrome
(complications)
- Transcranial Magnetic Stimulation
- Treatment Outcome
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