| Abstract |
A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characterization of the interesting compounds. |
| Authors | Bharat Lagu, Chrissy Gerchak, Meng Pan, Cuifen Hou, Monica Singer, Ravi Malaviya, Michele Matheis, Gil Olini, Druie Cavender, Michael Wachter |
| Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 17
Issue 15
Pg. 4382-6
(Aug 01 2007)
ISSN: 0960-894X [Print] England |
| PMID | 17587570
(Publication Type: Journal Article)
|
| Chemical References |
- Anti-Asthmatic Agents
- CCR2 protein, human
- Receptors, CCR2
- Receptors, Chemokine
|
| Topics |
- Anti-Asthmatic Agents
(therapeutic use)
- Asthma
(drug therapy)
- Humans
- Receptors, CCR2
- Receptors, Chemokine
(antagonists & inhibitors)
|
