Abstract | OBJECTIVE: METHODS: SD rats were subjected to 5/6 nephrectomy and fed 4% casein diet to induce chronic renal failure (CRF), and their blood urea nitrogen (BUN), serum creatinine (Scr), serum albumin (ALB), hemoglobin (Hb), 24-hour urineprotein (24-h Upro) and body weight were measured. Upon the onset of malnutrition, the rats were randomized into CRF control group (CC), ketosteril group (KT), and Shenshuai Yangzhen group (SSYZ), with also a normal control group (NC). After 4 weeks of treatment as indicated, the remnant nephrotic tissue was examined under optical and electron microscopes and by immunofluorescence assay. RESULTS:
Malnutrition occurred in the CRF rats at the end of the 10th weeks after the operation. Compared with those in CC group, the plasma BUN, SCr and 24-h Upro levels in SSYZ group were significantly lower with substantially elevated plasma ALB and Hb. The pathological changes of SSYZ group was significantly improved after treatment with Shenshuai Yangzhen capsule. CONCLUSION:
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Authors | Yu-ming Li, Lian-bo Wei, Cong Deng |
Journal | Nan fang yi ke da xue xue bao = Journal of Southern Medical University
(Nan Fang Yi Ke Da Xue Xue Bao)
Vol. 27
Issue 6
Pg. 787-91
(Jun 2007)
ISSN: 1673-4254 [Print] China |
PMID | 17584639
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Capsules
- Drugs, Chinese Herbal
- Serum Albumin
- shenshuai yangzhen
- Creatinine
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Topics |
- Animals
- Blood Urea Nitrogen
- Capsules
- Creatinine
(blood)
- Drugs, Chinese Herbal
(pharmacology)
- Kidney
(drug effects, surgery, ultrastructure)
- Kidney Failure, Chronic
(blood, complications, drug therapy)
- Male
- Malnutrition
(complications, drug therapy)
- Microscopy, Electron
- Nephrectomy
(methods)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Serum Albumin
(analysis)
- Treatment Outcome
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