[Experimental study on treating hyperlipidemic fatty liver with Taizhi'an capsule].

Abstract

OBJECTIVE:

To observe the effects of Taizhi'an capsule in treatment of hyperlipidemic fatty liver.

METHOD:

The model rats were induced by feeding high caloric diet for 8 weeks, then fifty rats were randomly divided into five groups, and each group had ten rats, the Taizhi'an groups (high dose 1 000 mg x kg(-1), middle dose 500 mg x kg(-1), low dose 250 mg x kg(-1)), the Yishanfu group and the model group. Liver index (liver weight/body weight), liver function, blood lipid, liver lipid, the content of MDA and SOD in liver were assayed after therapy, and observe Pathologic changes in rats liver.

RESULT:

Liver index, blood lipid, liver lipid, liver function increased significantly (P < 0.001) in model rats, and the content of SOD in liver decreased significantly (P < 0.05), Liver histology expressed mild to moderate fat denaturation; After being treated with high and middle dose of Taizhi'an capsule for six weeks, blood lipid, liver function decreased significantly (P < 0.001), and liver lipid decreased significantly (P < 0.001, P <0.05), the content of SOD in liver increased significantly (P < 0.05), meanwhile liver histology was closed to normal.

CONCLUSION:

Taizhian capsule is effective in the treatment of hyperlipidemic induced fatty liver.

• Authors: Mei Sun, Jian-Zhen Shan, Guo-Ping Zhang, Hua-Zhong Ying
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 32 Issue 7 Pg. 616-9 (Apr 2007) ISSN: 1001-5302 [Print] China
• PMID: 17583205 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Capsules
• Drugs, Chinese Herbal
• Triglycerides
• Triterpenes
• taizhi'an
• Malondialdehyde
• Cholesterol
• Superoxide Dismutase
• Aspartate Aminotransferases
• Alanine Transaminase
• ursolic acid

Topics

• Alanine Transaminase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Capsules
• Cholesterol (blood, metabolism)
• Drugs, Chinese Herbal (administration & dosage, pharmacology)
• Fatty Liver (drug therapy, etiology, metabolism)
• Hyperlipidemias (complications)
• Ligustrum (chemistry)
• Liver (drug effects, metabolism, pathology)
• Male
• Malondialdehyde (metabolism)
• Phytotherapy
• Plant Leaves (chemistry)
• Plants, Medicinal (chemistry)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Superoxide Dismutase (metabolism)
• Triglycerides (blood, metabolism)
• Triterpenes (administration & dosage, pharmacology)