Abstract |
It is uncertain how immunity protects against systemic viral diseases. Here, we demonstrate that in the absence of persistent virus, not only antibodies but also recall responses by long-lived memory CD8(+) T cells prevent mousepox, a disease caused by ectromelia virus, a close relative of the virus of human smallpox. Moreover, we show that to protect, recall CD8(+) T cells directly kill targets in the lymph node draining the primary site of infection thus curbing systemic viral spread. Therefore, our work provides the basis for a model where lymph nodes are not just organs where lymphocytes become activated and proliferate but also the sites where a major fight against virus spread takes place.
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Authors | Ren-Huan Xu, Min Fang, Andres Klein-Szanto, Luis J Sigal |
Journal | Proceedings of the National Academy of Sciences of the United States of America
(Proc Natl Acad Sci U S A)
Vol. 104
Issue 26
Pg. 10992-7
(Jun 26 2007)
ISSN: 1091-6490 [Electronic] United States |
PMID | 17578922
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Antibodies, Viral
- Antibody Formation
- CD8-Positive T-Lymphocytes
(immunology, physiology)
- Ectromelia, Infectious
(immunology)
- Immunologic Memory
- Lymph Nodes
(immunology)
- Mice
- Models, Biological
- Virus Diseases
(immunology)
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