Trigeminal autonomic cephalalgias: current and future treatments.

The trigeminal autonomic cephalgias include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT). The evidence for the current treatment options for each of these syndromes is considered, including oxygen, sumatriptan, and verapamil in cluster headache, indomethacin in paroxysmal hemicrania, and intravenous lidocaine and lamotrigine in SUNCT. Some treatments such as topiramate have an effect in all of these, as well as in migraine and other pain syndromes. The involvement of the hypothalamus in functional imaging studies implies that this may be a substrate for targeting treatment options in the future.
AuthorsAnna S Cohen, Manjit S Matharu, Peter J Goadsby
JournalHeadache (Headache) Vol. 47 Issue 6 Pg. 969-80 (Jun 2007) ISSN: 0017-8748 [Print] United States
PMID17578559 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants
  • Serotonin Receptor Agonists
  • Vasodilator Agents
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Anticonvulsants (therapeutic use)
  • Humans
  • Serotonin Receptor Agonists (therapeutic use)
  • Trigeminal Autonomic Cephalalgias (drug therapy, prevention & control)
  • Vasodilator Agents (therapeutic use)

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