| Abstract |
Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active. |
| Authors | Philip Wickens, Harold Kluender, Julie Dixon, Catherine Brennan, Furahi Achebe, Antonella Bacchiocchi, Don Bankston, Donald Bierer, Michael Brands, Debbie Braun, Melissa S Brown, Chih-Yuan Chuang, Jacques Dumas, Istvan Enyedy, Gloria Hofilena, Zhenqiu Hong, Tim Housley, Benjamin Jones, Uday Khire, Charles Kreiman, Ellalahewage Kumarasinghe, Timothy Lowinger, Ronda Ott-Morgan, Louise Perkins, Barton Phillips, Robert Schoenleber, William J Scott, Ryan Sheeler, Anikó Redman, Xiuying Sun, Ian Taylor, Lei Wang, Scott Wilhelm, Xiaomei Zhang, Mingbao Zhang, Elizabeth Sullivan, Christopher Carter, Mark Miglarese, Joan Levy |
| Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 17
Issue 15
Pg. 4378-81
(Aug 01 2007)
ISSN: 0960-894X [Print] England |
| PMID | 17574417
(Publication Type: Journal Article)
|
| Chemical References |
- Antineoplastic Agents
- Protein Kinase Inhibitors
- Vascular Endothelial Growth Factor Receptor-2
|
| Topics |
- Animals
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Cell Line, Tumor
- Humans
- Mice
- Neoplasms
(drug therapy)
- Protein Kinase Inhibitors
(pharmacology, therapeutic use)
- Structure-Activity Relationship
- Vascular Endothelial Growth Factor Receptor-2
(antagonists & inhibitors)
|
|
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