Abstract | OBJECTIVE:
Anal fissure is a common painful condition affecting the anal canal and causes considerable morbidity and reduction in quality of life. Surgical treatment has been associated with a degree of incontinence in up to 30% of patients. This study discussed the results of clove oil 1% cream in healing of chronic anal fissure. METHOD: A single-blind randomized comparative trial was setup to compare traditional treatment with stool softeners and lignocaine cream 5% against clove oil 1% cream for 6 weeks. RESULTS: 55 patients were included in this study, 30 patients in clove oil group and 25 patients in control group. Healing had occurred in 60% of patients in clove oil group and in 12% of patients in the control group after 3-month follow up (P < 0.001). Patients in clove oil group showed significant reduction in resting anal pressure and almost all other anorectal manometric pressures compared with patients in control group. CONCLUSION: Topical application of clove oil cream demonstrated a significant beneficial effect when applied to patients suffering from chronic anal fissure.
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Authors | H A Elwakeel, H A Moneim, M Farid, A A Gohar |
Journal | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
(Colorectal Dis)
Vol. 9
Issue 6
Pg. 549-52
(Jul 2007)
ISSN: 1462-8910 [Print] England |
PMID | 17573751
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Administration, Topical
- Adult
- Clove Oil
(administration & dosage, therapeutic use)
- Fissure in Ano
(drug therapy)
- Humans
- Middle Aged
- Phytotherapy
- Single-Blind Method
- Treatment Outcome
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