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Clove oil cream: a new effective treatment for chronic anal fissure.

AbstractOBJECTIVE:
Anal fissure is a common painful condition affecting the anal canal and causes considerable morbidity and reduction in quality of life. Surgical treatment has been associated with a degree of incontinence in up to 30% of patients. This study discussed the results of clove oil 1% cream in healing of chronic anal fissure.
METHOD:
A single-blind randomized comparative trial was setup to compare traditional treatment with stool softeners and lignocaine cream 5% against clove oil 1% cream for 6 weeks.
RESULTS:
55 patients were included in this study, 30 patients in clove oil group and 25 patients in control group. Healing had occurred in 60% of patients in clove oil group and in 12% of patients in the control group after 3-month follow up (P < 0.001). Patients in clove oil group showed significant reduction in resting anal pressure and almost all other anorectal manometric pressures compared with patients in control group.
CONCLUSION:
Topical application of clove oil cream demonstrated a significant beneficial effect when applied to patients suffering from chronic anal fissure.
AuthorsH A Elwakeel, H A Moneim, M Farid, A A Gohar
JournalColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (Colorectal Dis) Vol. 9 Issue 6 Pg. 549-52 (Jul 2007) ISSN: 1462-8910 [Print] England
PMID17573751 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Clove Oil
Topics
  • Administration, Topical
  • Adult
  • Clove Oil (administration & dosage, therapeutic use)
  • Fissure in Ano (drug therapy)
  • Humans
  • Middle Aged
  • Phytotherapy
  • Single-Blind Method
  • Treatment Outcome

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