[Response to idebenone and multivitamin therapy in Leber's hereditary optic neuropathy].

Abstract

OBJECTIVE:

To ascertain the efficacy of idebenone and multivitamin treatment in Leber's hereditary optic neuropathy (LHON).

METHOD:

Two patients diagnosed of unilateral LHON were treated with megadoses of idebenone, vitamin C and riboflavin for one year. They were examined clinically before, during and after treatment.

RESULTS:

No improvement of visual function was observed. Despite the idebenone treatment, in both cases the second eye became involved.

CONCLUSIONS:

Despite previous reports of visual recovery with idebenone in patients with LHON, our experience shows that an effective treatment for Leber's disease remains to be found.

• Authors: N Barnils, E Mesa, S Muñoz, A Ferrer-Artola, J Arruga
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 82 Issue 6 Pg. 377-80 (Jun 2007) ISSN: 0365-6691 [Print] Spain
• Vernacular Title: Respuesta a la idebenona asociada a multivitaminoterapia en neuropatía óptica hereditaria de Leber.
• PMID: 17573650 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antioxidants
• Benzoquinones
• Vitamins
• Vitamin B Complex
• Ubiquinone
• idebenone
• Ascorbic Acid
• Riboflavin

Topics

• Adult
• Antioxidants (therapeutic use)
• Ascorbic Acid (therapeutic use)
• Benzoquinones (therapeutic use)
• Female
• Humans
• Male
• Optic Atrophy, Hereditary, Leber (drug therapy)
• Riboflavin (therapeutic use)
• Treatment Failure
• Ubiquinone (analogs & derivatives)
• Vitamin B Complex (therapeutic use)
• Vitamins (therapeutic use)