Chronic rhinosinusitis and psoriasis: do mutually exclusive systemic Th1 and Th2 disease patterns exist?

Abstract

CONCLUSION:

Our results support the theory that chronic rhinosinusitis (CRS) is a systemic Th alteration, the relevance of which is discussed in detail.

OBJECTIVE:

CRS imposes a heavy burden on society; however, a reliable CRS therapy has not been found. Developing a better understanding of this pathology will help us in our search for more effective therapies. One question, which is rarely examined, is the possibility of CRS existing as a systemic immune alteration in Th response. Thus, the goal of this study was to examine the occurrence of CRS, a Th2 pathology, with Th1 pathologies such as psoriasis.

PATIENTS AND METHODS:

This study was performed via a retrospective electronic query of our medical center in regards to patients coded with the respective diagnosis.

RESULTS:

Analysis of the data showed that occurrence of CRS rarely coincided with the occurrence of psoriasis and other such Th1 pathologies.

• Authors: Rashid M Rashid, Andrew Miller, Joseph M Scianna, James A Stankiewicz
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 127 Issue 7 Pg. 780-3 (Jul 2007) ISSN: 0001-6489 [Print] England
• PMID: 17573576 (Publication Type: Journal Article)

Topics

• Arthritis, Rheumatoid (immunology)
• Chronic Disease
• Crohn Disease (immunology)
• Humans
• Multiple Sclerosis (immunology)
• Psoriasis (immunology)
• Retrospective Studies
• Rhinitis (immunology)
• Sinusitis (immunology)
• Th1 Cells (immunology)
• Th2 Cells (immunology)