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Comparison of Crinone 8% intravaginal gel and intramuscular progesterone supplementation for in vitro fertilization/embryo transfer in women under age 40: interim analysis of a prospective randomized trial.

Abstract
This study was performed to compare the efficacy of Crinone 8% intravaginal gel and intramuscular progesterone (IMP) supplementation for luteal phase support in women under age 40 undergoing IVF-ET. Results of the interim analysis of this rigorously designed prospective randomized controlled study are presented. Pregnancy rates, implantation rates, and early spontaneous abortion rates were similar for patients receiving Crinone or IMP, whereas fewer side effects and greater overall satisfaction were reported by women receiving Crinone.
AuthorsElena Yanushpolsky, Shelley Hurwitz, Louise Greenberg, Catherine Racowsky, Mark D Hornstein
JournalFertility and sterility (Fertil Steril) Vol. 89 Issue 2 Pg. 485-7 (Feb 2008) ISSN: 1556-5653 [Electronic] United States
PMID17572412 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Crinone
  • Vaginal Creams, Foams, and Jellies
  • Progesterone
Topics
  • Adult
  • Age Factors
  • Embryo Implantation (drug effects)
  • Embryo Transfer
  • Female
  • Fertilization in Vitro (methods)
  • Humans
  • Injections, Intramuscular
  • Maternal Age
  • Pregnancy
  • Pregnancy Rate
  • Progesterone (administration & dosage, analogs & derivatives)
  • Statistics as Topic (methods)
  • Treatment Outcome
  • Vaginal Creams, Foams, and Jellies (chemistry)

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