Abstract |
Arctiin, a plant lignan, is metabolized to hormone-like compounds with weak estrogenic and antioxidative activity in experimental animals and man. To clarify its influence on mammary carcinogenesis, female rats were administrated 7,12-dimethylbenz(a)anthracene (DMBA) once, and when the incidence of palpable mammary tumors reached 50%, subjected to ovariectomy (OVX) and divided into tumor-bearing [DMBA- Tumor (+)] and no- tumor-bearing [DMBA- Tumor (-)] groups, subgroups of each then being fed soybean-free diet containing 0, 40, 200, and 1000 ppm of arctiin for 31 wk. The incidence and multiplicity of palpable tumors in the 200 ppm DMBA- Tumor (+) subgroup from week 12 of arctiin treatment tended to be decreased as compared to the 0 ppm subgroup and at terminal sacrifice, the volume of histopathologically defined mammary tumors was decreased in the 40 ppm DMBA- Tumor (-) subgroup, but again without statistical significance. In conclusion, weak inhibitory effects of arctiin on DMBA-induced mammary tumor development were suggested in OVX rats, but any further assessment is needed to obtain conclusive results.
|
Authors | Mai Hasumura, Makoto Ueda, Jun-ichi Onose, Toshio Imai, Masao Hirose |
Journal | Nutrition and cancer
(Nutr Cancer)
Vol. 57
Issue 2
Pg. 201-8
( 2007)
ISSN: 0163-5581 [Print] United States |
PMID | 17571954
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anticarcinogenic Agents
- Carcinogens
- Furans
- Glucosides
- 9,10-Dimethyl-1,2-benzanthracene
- arctiin
|
Topics |
- 9,10-Dimethyl-1,2-benzanthracene
(toxicity)
- Animals
- Anticarcinogenic Agents
(pharmacology)
- Carcinogens
(toxicity)
- Cell Transformation, Neoplastic
- Disease Progression
- Dose-Response Relationship, Drug
- Female
- Furans
(pharmacology)
- Glucosides
(pharmacology)
- Incidence
- Mammary Neoplasms, Experimental
(chemically induced, epidemiology, prevention & control)
- Ovariectomy
- Random Allocation
- Rats
- Rats, Sprague-Dawley
|