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Lack of a significant effect of arctiin on development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats.

Abstract
Arctiin, a plant lignan, is metabolized to hormone-like compounds with weak estrogenic and antioxidative activity in experimental animals and man. To clarify its influence on mammary carcinogenesis, female rats were administrated 7,12-dimethylbenz(a)anthracene (DMBA) once, and when the incidence of palpable mammary tumors reached 50%, subjected to ovariectomy (OVX) and divided into tumor-bearing [DMBA-Tumor (+)] and no-tumor-bearing [DMBA-Tumor (-)] groups, subgroups of each then being fed soybean-free diet containing 0, 40, 200, and 1000 ppm of arctiin for 31 wk. The incidence and multiplicity of palpable tumors in the 200 ppm DMBA-Tumor (+) subgroup from week 12 of arctiin treatment tended to be decreased as compared to the 0 ppm subgroup and at terminal sacrifice, the volume of histopathologically defined mammary tumors was decreased in the 40 ppm DMBA-Tumor (-) subgroup, but again without statistical significance. In conclusion, weak inhibitory effects of arctiin on DMBA-induced mammary tumor development were suggested in OVX rats, but any further assessment is needed to obtain conclusive results.
AuthorsMai Hasumura, Makoto Ueda, Jun-ichi Onose, Toshio Imai, Masao Hirose
JournalNutrition and cancer (Nutr Cancer) Vol. 57 Issue 2 Pg. 201-8 ( 2007) ISSN: 0163-5581 [Print] United States
PMID17571954 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticarcinogenic Agents
  • Carcinogens
  • Furans
  • Glucosides
  • 9,10-Dimethyl-1,2-benzanthracene
  • arctiin
Topics
  • 9,10-Dimethyl-1,2-benzanthracene (toxicity)
  • Animals
  • Anticarcinogenic Agents (pharmacology)
  • Carcinogens (toxicity)
  • Cell Transformation, Neoplastic
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Female
  • Furans (pharmacology)
  • Glucosides (pharmacology)
  • Incidence
  • Mammary Neoplasms, Experimental (chemically induced, epidemiology, prevention & control)
  • Ovariectomy
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley

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