Anti-inflammatory activity of flavonoids from Eupatorium arnottianum.

Abstract	Three anti-inflammatory compounds: nepetin, jaceosidin and hispidulin have been isolated and identified from Eupatorium arnottianum Griseb. dichloromethane extract. Nepetin reduced the TPA mouse ear edema by 46.9% and jaceosidin by 23.2% (1mg/ear). Both compounds inhibited the NF kappaB induction by 91 and 77%, respectively. Furthermore phytochemical analysis of the ethanol extract has led to the identification of eriodictyol, hyperoside, rutin, caffeic and chlorogenic acids. All these compounds are reported for the first time in this species. The finding of topical antiinflammatory activity exerted by Eupatorium arnottianum extract and the identification of active principles could support the use of this plant for the treatment of inflammatory affections.
Authors	M Clavin, S Gorzalczany, A Macho, E Muñoz, G Ferraro, C Acevedo, V Martino
Journal	Journal of ethnopharmacology (J Ethnopharmacol) Vol. 112 Issue 3 Pg. 585-9 (Jul 25 2007) ISSN: 0378-8741 [Print] Ireland
PMID	17570627 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Inflammatory Agents Caffeic Acids Flavanones Flavones Flavonoids Plant Extracts jaceosidin hyperoside Carrageenan Quercetin eupafolin hispidulin Tetradecanoylphorbol Acetate eriodictyol caffeic acid
Topics	Animals Anti-Inflammatory Agents (chemistry, isolation & purification, pharmacology) Caffeic Acids (chemistry, isolation & purification, pharmacology) Carrageenan (toxicity) Cell Survival (drug effects) Dose-Response Relationship, Drug Ear, External (drug effects, pathology) Edema (chemically induced, prevention & control) Eupatorium (chemistry) Female Flavanones (chemistry, isolation & purification, pharmacology) Flavones (chemistry, isolation & purification, pharmacology) Flavonoids (chemistry, isolation & purification, pharmacology) HeLa Cells Humans Jurkat Cells Mice Molecular Structure Plant Extracts (chemistry, isolation & purification, pharmacology) Quercetin (analogs & derivatives, chemistry, isolation & purification, pharmacology) Rats Rats, Sprague-Dawley Tetradecanoylphorbol Acetate (toxicity)

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