Abstract |
A study on the bioavailability and pharmacokinetics of florfenicol was conducted in six healthy dogs following a single intravenous (i.v.) or oral (p.o.) dose of 20 mg kg(-1) body weight (b.w.). Florfenicol concentrations in serum were determined by a high-performance liquid chromatography/mass spectrometry. Plasma concentration-time data after p.o. or i.v. administration were analyzed by a non-compartmental analysis. Following i.v. injection, the total body clearance was 1.03 (0.49) L kg(-1)h(-1) and the volume of distribution at steady-state was 1.45 (0.82) L kg(-1). Florfenicol was rapidly distributed and eliminated following i.v. injection with 1.11 (0.94)h of the elimination half-life. After oral administration, the calculated mean C(max) values (6.18 microg ml(-1)) were reached at 0.94 h in dogs. The elimination half-life of florfenicol was 1.24 (0.64) h and the absolute bioavailability (F) was achieved 95.43 (11.60)% after oral administration of florfenicol. Florfenicol amine, the major metabolite of florfenicol, was detected in all dogs after i.v. and p.o. administrations.
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Authors | Byung-Kwon Park, Jong-Hwan Lim, Myoung-Seok Kim, Youn-Hwan Hwang, Hyo-In Yun |
Journal | Research in veterinary science
(Res Vet Sci)
Vol. 84
Issue 1
Pg. 85-9
(Feb 2008)
ISSN: 0034-5288 [Print] England |
PMID | 17570454
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- florfenicol amine
- florfenicol
- Thiamphenicol
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Topics |
- Administration, Oral
- Animals
- Anti-Bacterial Agents
(administration & dosage, chemistry, pharmacokinetics)
- Area Under Curve
- Biological Availability
- Cross-Over Studies
- Dogs
(metabolism)
- Half-Life
- Injections, Intravenous
- Male
- Molecular Structure
- Thiamphenicol
(administration & dosage, analogs & derivatives, chemistry, pharmacokinetics)
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