[Aike mixture has good anti-inflammatory and analgesic effects on mice].

Abstract

OBJECTIVE:

To study the anti-inflammatory and analgesic actions of Aike Mixture (AKM).

METHODS:

A total of 100 male mice were randomly assigned into 5 groups: a normal control group, a drug control group (a hydrocortisone subgroup and an atropine subgroup), a high-dose AKM group, a mid-dose AKM group and a low-dose AKM group. Xylene was spread on the left ear of the experimental mice to induce inflammation, and 1% acetic acid solution injected into the abdominal cavity to produce pain so as to cause the body bend. Different doses of AKM were given and their actions observed.

RESULTS:

AKM had obvious anti-inflammatory effect on the xylene-induced ear tumefaction and inhibited the pain-caused body bend in the AKM groups, with significant difference from the normal control (P < 0.01).

CONCLUSION:

AKM has good anti-inflammatory and analgesic effects, which is of clinical significance in the treatment of chronic prostatitis.

• Authors: Min-jian Zhang, Ke-dan Chu, Xin-ling Cheng, Xu-dong Pan, Wan-jun Cheng, Kai-yuan Yu, Yu-hong Tan, Jin-zhi Liu, Ya-lei Shi, Sheng Zheng, Qiao-bin Liu
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 13 Issue 5 Pg. 471-3 (May 2007) ISSN: 1009-3591 [Print] China
• PMID: 17569268 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Saponins
• Oleanolic Acid
• saikosaponin D

Topics

• Animals
• Chronic Disease
• Disease Models, Animal
• Drug Combinations
• Male
• Mice
• Mice, Inbred ICR
• Oleanolic Acid (analogs & derivatives, pharmacology, therapeutic use)
• Phytotherapy
• Prostatitis (drug therapy)
• Saponins (pharmacology, therapeutic use)