Advanced oxidation protein products, ferrous oxidation in xylenol orange, and malondialdehyde levels in thyroid cancer.

Abstract

AIMS AND BACKGROUND:

The oxidation of protein plays an essential role in the pathogenesis of an important number of degenerative and cancer diseases, which is now widely recognized. The aim is to examine advanced oxidation protein products (AOPPs), lipid peroxidation products malondialdehyde (MDA), and ferrous oxidation in xylenol orange (FOX) in blood samples of papillary thyroid cancer patients compared with healthy controls to determine the oxidation status and the change after thyroidectomy.

METHODS:

Thirty-five female thyroid cancer patients who underwent total thyroidectomy and 39 female control subjects were included into this study. Prethyroidectomy and postthyroidectomy, AOPP, FOX, and MDA levels were studied.

RESULTS:

Prethyroidectomy AOPP, FOX, and MDA levels were significantly higher compared to control (P < .05). In postthyroidectomy AOPP, FOX, and MDA levels were significantly decreased compared with prethyroidectomy levels (P < .05). However, postthyroidectomy levels on the 20th day were still significantly higher, compared to control subjects (P < .05).

CONCLUSION:

In conclusion, all of AOPP, FOX, and MDA levels that are markers of protein oxidation and lipid hyperoxidation may induce thyroid cancer development and begin to decrease after thyroidectomy.

• Authors: Funda Kosova, Bahadir Cetin, Melih Akinci, Sabahattin Aslan, Zeki Ari, Aylin Sepici, Nilgün Altan, Abdullah çetin
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 14 Issue 9 Pg. 2616-20 (Sep 2007) ISSN: 1068-9265 [Print] United States
• PMID: 17564752 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Blood Proteins
• Ferrous Compounds
• Phenols
• Sulfoxides
• Xylenes
• Malondialdehyde
• xylenol orange

Topics

• Adult
• Biomarkers, Tumor (blood)
• Blood Proteins (metabolism)
• Female
• Ferrous Compounds (blood)
• Humans
• Lipid Peroxidation
• Male
• Malondialdehyde (blood)
• Oxidation-Reduction
• Phenols
• Radioimmunoassay
• Statistics, Nonparametric
• Sulfoxides
• Thyroid Neoplasms (blood, surgery)
• Thyroidectomy
• Xylenes