HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Depletion of calcitonin gene-related peptide in perivascular nerves during acute phase of posthemorrhagic vasospasm in the rabbit.

Abstract
The behaviour of various neuropeptides during early and late vasospasm following experimental subarachnoid hemorrhage has been investigated by several authors. Recently, a reduction of the content of vasodilatory neuropeptides (vasodilatory intestinal peptide, substance P and calcitonin gene-related peptide) has been demonstrated in the perivascular nerves of cerebral arteries after few days from induction of experimental subarachnoid hemorrhage. In the present immunohistochemical study, the authors investigated secretion and expression of CGRP a few minutes after injection of autologous blood into the cisterna magna of the rabbit. The authors propose that the marked decrease of calcitonin gene-related peptide immunoreactivity in the perivascular nerves, observed after experimental subarachnoid hemorrhage, is due to compensatory secretion of the peptide.
AuthorsC Arienta, S Balbi, M Caroli, G Fumagalli
JournalBrain research bulletin (Brain Res Bull) Vol. 27 Issue 5 Pg. 605-9 (Nov 1991) ISSN: 0361-9230 [Print] United States
PMID1756379 (Publication Type: Journal Article)
Chemical References
  • Calcitonin Gene-Related Peptide
Topics
  • Animals
  • Basilar Artery (innervation, physiopathology)
  • Calcitonin Gene-Related Peptide (metabolism)
  • Female
  • Ischemic Attack, Transient (physiopathology)
  • Male
  • Peripheral Nerves (physiopathology)
  • Rabbits
  • Subarachnoid Hemorrhage (physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: