Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse.

Abstract

BACKGROUND:

Manganese intoxication may lead to a levodopa-resistant, akinetic-rigid syndrome. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone).

PATIENT:

A 36-year-old man from Azerbaijan with hepatitis C and only modest hepatic synthetic dysfunction developed rapid-onset, levodopa-resistant parkinsonism with profound hypophonia.

CONCLUSION:

Ephedronic encephalopathy outside the region of the former Soviet Union may become a more widespread public health problem as a result of global travel and the easy availability of the recipe for synthesis of methcathinone on the Internet.

• Authors: Rob M A de Bie, Richard M Gladstone, Antonio P Strafella, Ji-Hyun Ko, Anthony E Lang
• Journal: Archives of neurology (Arch Neurol) Vol. 64 Issue 6 Pg. 886-9 (Jun 2007) ISSN: 0003-9942 [Print] United States
• PMID: 17562938 (Publication Type: Case Reports, Journal Article)

Chemical References

• Propiophenones
• monomethylpropion

Topics

• Adult
• Brain Diseases (chemically induced, diagnosis)
• Humans
• Magnetic Resonance Imaging
• Male
• Manganese Poisoning (complications)
• Parkinsonian Disorders (chemically induced, diagnosis, physiopathology)
• Propiophenones (adverse effects)
• Substance-Related Disorders (complications)