Abstract | OBJECTIVES: METHODS: Systematic review of the literature and meta-analysis. We searched for randomized controlled trials comparing the efficacy of single aminoglycoside antibiotic treatment with one or more non- aminoglycoside antibiotic for patients with infection in the Cochrane Library, MEDLINE, EMBASE, LILACS, databases of ongoing trials and conference proceedings. Two reviewers assessed trial eligibility, quality and extracted data. Pooled relative risks (RR) with 95% confidence intervals (CI) were calculated for dichotomous data. RESULTS: The search yielded 37 trials of which 26 included patients with urinary tract infection. Aminoglycosides were equally effective as comparators in the analysis of the primary outcomes, all-cause mortality (RR 1.11, 95% CI 0.68, 1.81, 9 trials, 503 patients) and treatment failure (RR 1.10, 95% CI 0.96, 1.27, 32 trials, 1890 patients). Aminoglycosides were associated with a significantly higher rate of bacteriological failure at end of therapy (RR 1.44, 95% CI 1.21, 1.72, 27 trials, 1668 patients). Subgroup analyses according to quality of trial, type of antibiotics, source of infection and rate of clinical sepsis did not alter the outcomes. Less adverse effects in total but more nephrotoxic effects were observed in patients treated with aminoglycosides. CONCLUSIONS:
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Authors | Liat Vidal, Anat Gafter-Gvili, Sara Borok, Abigail Fraser, Leonard Leibovici, Mical Paul |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 60
Issue 2
Pg. 247-57
(Aug 2007)
ISSN: 0305-7453 [Print] England |
PMID | 17562680
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Aminoglycosides
- Anti-Bacterial Agents
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Topics |
- Aminoglycosides
(adverse effects, therapeutic use)
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Bacterial Infections
(drug therapy, mortality)
- Data Interpretation, Statistical
- Drug Resistance, Bacterial
- Humans
- Randomized Controlled Trials as Topic
- Sepsis
(drug therapy, mortality)
- Treatment Outcome
- Urinary Tract Infections
(drug therapy, microbiology)
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