Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case.

• Abstract: We report a case of a 68-year-old man presented with upper-gastrointestinal bleeding. Endoscopy showed a large ulcerated gastric mass. Histological examination of the gastric biopsies revealed a k monoclonal extramedullary plasmacytoma (EMP). Further staging was negative for multiple myeloma. The patient was managed with bortezomib at a dose of 1.3mg/m2 on days 1, 4, 8 and 11 of a 21-day cycle in combination with dexamethasone 20mg p.o. on days 1, 2, 4, 5, 8, 9 and 11, 12 of each cycle. After 4 cycles of treatment, no endoscopic or histological findings of EMP were found. Thirteen months after diagnosis the patient is in complete remission with no evidence of local relapse or evolution to multiple myeloma. This is the first reported case of EMP successfully managed with the combination of bortezomib and dexamethasone.
• Authors: Eirini Katodritou, Charalambos Kartsios, Vassiliki Gastari, Evgenia Verrou, Dimitra Mihou, Anastasia Banti, Georgia Lazaraki, Anna Lazaridou, Vassiliki Kaloutsi, Konstantinos Zervas (Affiliation: Theagenion Cancer Center, Hematology, Eyrygeni 6B, 54249 Thessaloniki, Greece. ikatodritou at otenet.gr)
• Journal: Leukemia research (Leuk Res) Vol. 32 Issue 2 Pg. 339-41 (Feb 2008) ISSN: 0145-2126 [Print] England
• PMID: 17560647 (Publication Type: Case Reports, Journal Article)

Chemical References

• Boronic Acids
• Pyrazines
• bortezomib
• Dexamethasone

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Boronic Acids (administration & dosage)
• Dexamethasone (administration & dosage)
• Humans
• Male
• Middle Aged
• Plasmacytoma (drug therapy, pathology, physiopathology)
• Pyrazines (administration & dosage)
• Stomach Neoplasms (drug therapy, pathology, physiopathology)