Abstract | BACKGROUND: RESULTS: Versus an isotonic suspension, the hypotonic suspension achieved higher concentrations of des-CIC (5.6-fold, 11.4-fold, and 13.4-fold; p < 0.05 for all) and ciclesonide (25.3-fold, 34.2-fold [p = not significant], and 16-fold [p < 0.05]) at 30, 120, and 240 min postadministration. Additionally, when administered via a hypotonic suspension, des-CIC was retained up to 24 h postadministration (45.46 pmol/g tissue). Highest concentration of major fatty acid ester conjugate, des-CIC- oleate, was detected in nasal mucosa at 8 h postadministration. CONCLUSION:
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Authors | Hideyuki Sato, Ruediger Nave, Takashi Nonaka, Nishibe Yoshihisa, Nagano Atsuhiro, Tsutomu Mochizuki, Shigehiro Takahama, Shiro Kondo, Mark Wingertzahn |
Journal | BMC pharmacology
(BMC Pharmacol)
Vol. 7
Pg. 7
(Jun 06 2007)
ISSN: 1471-2210 [Electronic] England |
PMID | 17553148
(Publication Type: Journal Article)
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Chemical References |
- Anti-Allergic Agents
- Esters
- Fatty Acids
- Hypotonic Solutions
- Isotonic Solutions
- Pregnenediones
- Suspensions
- desisobutyrylciclesonide
- ciclesonide
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Topics |
- Administration, Intranasal
- Animals
- Anti-Allergic Agents
(administration & dosage, metabolism, pharmacokinetics)
- Chromatography, High Pressure Liquid
- Drug Administration Schedule
- Esters
(metabolism)
- Fatty Acids
(metabolism)
- Hypotonic Solutions
- Isotonic Solutions
- Male
- Nasal Mucosa
(metabolism)
- Pregnenediones
(administration & dosage, metabolism, pharmacokinetics)
- Rabbits
- Suspensions
- Tandem Mass Spectrometry
- Time Factors
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