Acute colonic pseudo-obstruction in postchemotherapy complication of brain tumor treated with neostigmine.

Abstract

Acute colonic pseudo-obstruction is characterized by dilatation of the large bowel without mechanical obstruction. Although the first step of the treatment is conservative management, mechanical decompression should be performed when symptoms persist. Recently, the efficacy of pharmacologic treatment has been reported in adults, but no such data have yet been reported in children for treatment of acute colonic pseudo-obstruction resulting from chemotherapy. We report a 9-year-old boy with acute colonic pseudo-obstruction caused by chemotherapy for brain tumor who did not respond to initial supportive therapy, but who was successfully treated with neostigmine.

• Authors: Tai-Sung Kim, Jae-Wook Lee, Min-Ji Kim, Young-Shil Park, Dae-Hyoung Lee, Nak-Gyun Chung, Bin Cho, Soonju Lee, Hack-Ki Kim
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 29 Issue 6 Pg. 420-2 (Jun 2007) ISSN: 1077-4114 [Print] United States
• PMID: 17551407 (Publication Type: Case Reports, Journal Article)

Chemical References

• Neostigmine

Topics

• Acute Disease
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Brain Neoplasms (drug therapy)
• Cecum (pathology)
• Child
• Colon (pathology)
• Colonic Pseudo-Obstruction (chemically induced, drug therapy)
• Humans
• Male
• Neostigmine (therapeutic use)