Combined modality therapy of esthesioneuroblastoma.

Abstract

OBJECTIVE:

Esthesioneuroblastoma (ENB) is a rare tumor of the olfactory epithelium. The objective of this study was to evaluate treatment modalities including surgery, IMRT, and chemotherapy and patient outcomes.

PATIENTS AND METHODS:

A retrospective analysis was performed on a total of 21 patients. Therapy included craniofacial resection (CFR), radiotherapy, chemotherapy, or a combination of these methods.

RESULTS:

The median follow-up period was 47 months. Surgery was performed in 90.4% of cases; radiotherapy was performed adjuvantly in 15 (72.7%) patients. Surgery, radiotherapy, and chemotherapy were administered to 7 (33.3%) patients. Eight (38.3%) patients had local recurrence. The 5-year crude overall survival was 71.4% and actuarial 5-year overall survival was 58% with confidence interval (CI, 25 and 81, respectively). The 5-year crude disease-free survival rate was 59% and the 5-year actuarial disease-free survival rate was 62% (CI, 28 and 83, respectively).

CONCLUSION:

Multidisciplinary therapy of ENB should be considered, especially for Kadish C and high-grade lesions. Craniofacial resection (CFR), Intensity modulated radiation therapy (IMRT), and chemotherapy should be investigated in a multi-institution trial of ENB.

• Authors: J Nicolas McLean, Sunjay R Nunley, Carmen Klass, Charles Moore, Susan Müller, Peter A S Johnstone
• Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 136 Issue 6 Pg. 998-1002 (Jun 2007) ISSN: 0194-5998 [Print] England
• PMID: 17547995 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor

Topics

• Biomarkers, Tumor (analysis)
• Combined Modality Therapy
• Disease Progression
• Disease-Free Survival
• Esthesioneuroblastoma, Olfactory (diagnosis, pathology, therapy)
• Follow-Up Studies
• Humans
• Nasal Cavity
• Neoplasm Staging
• Nose Neoplasms (diagnosis, pathology, therapy)
• Olfactory Mucosa (pathology)
• Retrospective Studies