HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Fosamprenavir calcium plus ritonavir for HIV infection.

Abstract
Fosamprenavir is a protease inhibitor (PI) approved for the treatment of HIV-1 infection. Fosamprenavir is a prodrug of amprenavir developed to reduce the pill burden yet maintain the unique resistance pattern and efficacy associated with amprenavir. In a head-to-head, noninferiority trial in antiretroviral treatment-naive HIV-infected patients, the antiviral efficacy and tolerability of ritonavir-boosted fosamprenavir was not inferior to ritonavir-boosted lopinavir, when the PIs were combined with two other nucleoside reverse transcriptase inhibitors. There are fewer studies published about fosamprenavir use in antiretroviral treatment-experienced HIV-infected patients. The high genetic barrier to the development of resistance to fosamprenavir and the low level of cross-resistance between ritonavir-boosted fosamprenavir and other PI regimens are notable. As with amprenavir, gastrointestinal disturbance and rash are the most frequent short-term treatment-limiting events with fosamprenavir. Treatment with ritonavir-boosted fosamprenavir can produce a durable response. To date, fosamprenavir is one of the recommended preferred PI components for the treatment of antiretroviral-naive HIV-infected patients.
AuthorsHarrys A Torres, Roberto C Arduino
JournalExpert review of anti-infective therapy (Expert Rev Anti Infect Ther) Vol. 5 Issue 3 Pg. 349-63 (Jun 2007) ISSN: 1744-8336 [Electronic] England
PMID17547501 (Publication Type: Journal Article, Review)
Chemical References
  • Carbamates
  • Furans
  • HIV Protease Inhibitors
  • Organophosphates
  • Sulfonamides
  • HIV Protease
  • Ritonavir
  • fosamprenavir
Topics
  • Carbamates (administration & dosage, pharmacology, therapeutic use)
  • Clinical Trials as Topic
  • Drug Resistance, Viral
  • Drug Therapy, Combination
  • Exanthema (chemically induced, pathology)
  • Furans
  • HIV Infections (drug therapy)
  • HIV Protease (genetics)
  • HIV Protease Inhibitors (administration & dosage, pharmacology, therapeutic use)
  • HIV-1 (drug effects, genetics)
  • Humans
  • Organophosphates (administration & dosage, pharmacology, therapeutic use)
  • Ritonavir (administration & dosage, pharmacology, therapeutic use)
  • Sulfonamides (administration & dosage, pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: