Effects of exercise in overweight Japanese with multiple cardiovascular risk factors.

Abstract

PURPOSE:

The effects of exercise in subjects with multiple cardiovascular risk factors (RF) have never been tested in a large-scale randomized controlled trial. The favorable results from our observational study led to this randomized controlled trial.

METHODS:

The participants, recruited from a community, were overweight, with two of the following three risk factors: hypertension, hyperlipidemia, or glucose intolerance (N=561; 44% male; mean age (SD) 67 (6); mean BMI 26.4 (2.0)). All participants received a standard health exam with counseling, followed by randomization. The intervention group (INT) was to exercise two to four times per week for 6 months at a fitness club.

RESULTS:

Dropout rate was 11% for INT and 10% for the controls. INT exercised an average of 2.6 times per week. Among primary outcome measures, there was a marginally significant between-group difference in changes in systolic blood pressure (intervention minus control, -2.46 mm Hg). Reductions in LDL cholesterol (-1.9 mg.dL) and hemoglobin A1c (-0.042%) were not significant. Among secondary outcomes, between-group differences were significantly greater (P<0.05) for INT in mean body weight (-1.60 kg), waist circumference (-1.8 cm), triglyceride (-7 mg.dL), hsCRP (-0.063 mg.L), and estimated VO2peak (2.0 mL.kg.min). All directional mean RF changes consistently favored INT. A cardiovascular risk reduction estimated from the changes in RF was about 24%. A greater improvement was also found in health-related quality-of-life measures (SF-36) in INT. No difference was found in the adverse event rate.

CONCLUSIONS:

Exercising an average of 2.6 times per week for 6 months produced a significant improvement in cardiovascular risk profile in subjects with multiple cardiovascular risk factors through cumulative results of modest yet pervasive changes in all conventional risk factors, without increased adverse effects.

• Authors: Hirotaka Nishijima, Keiji Satake, Kumiko Igarashi, Noriteru Morita, Naomi Kanazawa, Koichi Okita
• Journal: Medicine and science in sports and exercise (Med Sci Sports Exerc) Vol. 39 Issue 6 Pg. 926-33 (Jun 2007) ISSN: 0195-9131 [Print] United States
• PMID: 17545881 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Cardiovascular Diseases (etiology)
• Exercise (physiology)
• Female
• Humans
• Japan
• Male
• Middle Aged
• Overweight
• Risk Factors