| Abstract | HAART has decreased the incidence of AIDS and death among HIV-infected individuals dramatically. This approach often becomes cumbersome to patients, involving multiple drugs administered on varying schedules. We investigated the pharmacokinetics, efficacy, and tolerability of a once-daily regimen of fosamprenavir, tenofovir, emtricitabine and ritonavir in HIV-infected treatment-naive subjects. No clinically significant interaction between the drugs was noted, and the regimen showed good efficacy and tolerability over the course of 48 weeks. |
| Authors | David A Parks, Harold C Jennings, Christopher W Taylor, Edward P Acosta
(Affiliation: Central West Clinical Research, St Louis, Missouri, USA.)
|
| Journal | AIDS (London, England)
(AIDS)
Vol. 21
Issue 10
Pg. 1373-5
(Jun 19 2007)
ISSN: 0269-9370 England |
| PMID | 17545719
(Publication Type: Journal Article)
|
| Chemical References |
- Antiviral Agents
- Carbamates
- HIV Protease Inhibitors
- Phosphonic Acids
- Phosphoric Acid Esters
- RNA, Viral
- Reverse Transcriptase Inhibitors
- Ritonavir
- Sulfonamides
- emtricitabine
- fosamprenavir
- tenofovir disoproxil
- Adenine
- Deoxycytidine
|
| Topics |
- Adenine
(administration & dosage, analogs & derivatives, blood, pharmacokinetics)
- Adolescent
- Adult
- Antiviral Agents
(administration & dosage, blood, pharmacokinetics)
- Carbamates
(administration & dosage, blood, pharmacokinetics)
- Deoxycytidine
(administration & dosage, analogs & derivatives, blood, pharmacokinetics)
- Drug Administration Schedule
- Drug Therapy, Combination
- HIV Infections
(blood, drug therapy)
- HIV Protease Inhibitors
(administration & dosage, blood, pharmacokinetics)
- Humans
- Phosphonic Acids
(administration & dosage, blood, pharmacokinetics)
- Phosphoric Acid Esters
(administration & dosage, blood, pharmacokinetics)
- RNA, Viral
(analysis)
- Reverse Transcriptase Inhibitors
(administration & dosage, blood, pharmacokinetics)
- Ritonavir
(administration & dosage, blood, pharmacokinetics)
- Sulfonamides
(administration & dosage, blood, pharmacokinetics)
- Treatment Outcome
|
